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目的 探讨血清C反应蛋白（CRP）、白细胞介素6(IL-6)及B型脑钠肽（BNP）水平对老年慢性心力衰竭患者并发肺部感染的预测价值。方法 选取2022年1月—2023年6月西安市人民医院（西安市第四医院）收治的112例老年慢性心力衰竭患者，根据是否并发肺部感染将其分为感染（n=46例）、未感染（n=66例），比较两者的一般病例资料和低蛋白血症、贫血、转氨酶异常、肾功能不全例数及血清CRP、IL-6、BNP水平。采用logistic回归分析老年慢性心力衰竭患者并发肺部感染的影响因素。绘制受试者工作特征（ROC）曲线，分析CRP、IL-6、BNP预测老年慢性心力衰竭患者并发肺部感染的效能。结果 血清CRP(OR=1.068,95%CI:1.011～1.127,P=0.018)、IL-6(OR=1.153,95%CI:1.032～1.287,P=0.012)、BNP(OR=1.007,95%CI:1.001～1.014,P=0.018)水平是老年慢性心力衰竭患者并发肺部感染的影响因素。ROC曲线分析显示，CRP、IL-6、BNP和三者联合预测老年慢性心力衰竭患者并发肺部感染的ROC曲线下面积分别为0.910、0.910、0.647、0.939，敏感性分别为73.90%、82.60%、50.00%、84.80%，特异性分别为92.40%、87.90%、78.80%、93.90%。结论 血清CRP、IL-6、BNP水平是老年慢性心力衰竭患者并发肺部感染的影响因素，三者联合检测对于老年慢性心力衰竭患者并发肺部感染具有预测价值。
Abstract：Objective To investigate the predictive value of serum C-reactive protein(CRP), Interleukin-6(IL-6) combined with B-type natriuretic peptide(BNP) in elderly patients with chronic heart failure complicated with pulmonary infection. Methods A total of 112 elderly patients with chronic heart failure admitted to Xi'an People's Hospital(Xi'an Fourth Hospital) from January 2022 to June 2023 were selected and divided into aninfected group(n=46) and an uninfected group(n=66) according to whether they had a concurrent pulmonary infection. The general case data and the number of cases with hypoproteinemia, anemia, abnormal transaminase, renal insufficiency, as well as the levels of CRP, IL-6 and BNP indices of the patients in the two groups were compared with each other. Logistic regression was used to analyze the influencing factors of pulmonary infection in elderly patients with chronic heart failure. The receiver operating characteristic(ROC) curve was plotted to analyze the efficacy of CRP, IL-6 and BNP in predicting pulmonary infection in elderly patients with chronic heart failure. Results The levels of serum CRP(OR=1. 068, 95% CI:1. 011-1. 127, P=0. 018), IL-6(OR=1. 153, 95% CI:1. 032-1. 287, P=0. 012), BNP(OR=1. 007, 95% CI:1. 001-1. 014, P=0. 018) were influencing factors for pulmonary infection in elderly patients with chronic heart failure. The ROC curve analysis showed that the areas under the ROC curve for CRP, IL-6, BNP, and their combination in predicting the occurrence of pulmonary infection in elderly patients with chronic heart failure were 0. 910, 0. 910, 0. 647, and 0. 939 respectively, with sensitivities of 73. 90%, 82. 60%, 50. 00%, and 84. 80% respectively, and specificities of 92. 40%, 87. 90%, 78. 80%, and 93. 90% respectively. Conclusions The levels of serum CRP, IL-6 and BNP are influencing factors for pulmonary infection in elderly patients with chronic heart failure. The combined detection of these three indicators has predictive value for the occurrence of pulmonary infection in elderly patients with chronic heart failure.
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基本信息:
DOI：
中图分类号:R563.1;R541.6
引用信息:
[1]刘雅琳,王峰.血清CRP、IL-6、BNP水平对老年慢性心力衰竭患者并发肺部感染的预测价值[J].老年医学研究,2025,6(04):5-9.
基金信息: