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胰高血糖素样肽-1受体激动剂(GLP-1RA)是近年来降糖药物的一个热点研究方向。GLP-1RA主要通过刺激胰岛素分泌、减少内源性葡萄糖生成、延缓胃排空、改善胰岛素敏感性和胰岛β细胞功能等方面来发挥降糖作用。GLP-1RA具有良好的降糖作用,还可以降低患者体质量、血压,部分GLP-1RA还可以有保护心血管和肾脏的作用。GLP-1RA不良反应较少,主要有胃肠道不良反应、心率增加、低血糖反应。
Abstract:Glucagon-like peptide-1 receptor agonist(GLP-1RA)is a hot research direction of hypoglycemic drugs in recent years. GLP-1RA exerts its hypoglycemic effect mainly by stimulating insulin secretion,reducing endogenous glucose production,delaying gastric emptying,improving insulin sensitivity and islet β-cell function and so on. GLP-1RA has a good hypoglycemic effect,but can also reduce the body weight and blood pressure of patients,some GLP-1RA can also protect cardiovascular and kidney. The adverse reactions of GLP-1RA were less,mainly gastrointestinal adverse reactions,increased heart rate and hypoglycemia.
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基本信息:
DOI:
中图分类号:R587.1
引用信息:
[1]赵延珍,杜婧.GLP-1受体激动剂治疗2型糖尿病的研究进展[J].老年医学研究,2021,2(03):55-60.
基金信息: