老年医学研究

2025, 01, v.6 77-80

三酰甘油—葡萄糖指数在心力衰竭中的应用进展

1.山东省枣庄市市中区人民医院心血管内科 2.山东大学齐鲁医院心内科,山东大学教育部与国家卫生健康委员会心血管重构与功能研究重点实验室

基金项目(Foundation):

邮箱(Email):

DOI:

72	0	86
下载次数	被引频次	阅读次数

引用本文下载本文

PDF

引用导出

GB/T 7714-2015 MLA APA Refworks EndNote NoteExpress NoteFirst

摘要全文参考文献出版信息相关文章

摘要：

三酰甘油—葡萄糖（TyG）指数作为评估胰岛素抵抗的可靠指标，近年来在心血管疾病领域也受到了广泛的关注。大量研究表明TyG指数与心血管疾病的发生、发展及预后密切相关。此外，人体成分参数如体质量指数、腰围身高比等也被认为与心力衰竭的发生和发展密切相关。本文旨在探讨TyG指数升高及其与人体测量学指标（体质量指数和腰围身高比）相结合在心力衰竭发病及不良预后中的应用进展，以期为临床实践提供理论依据。

关键词： 心力衰竭; 三酰甘油—葡萄糖指数; 体质量指数; 腰围身高比;

Abstract：

The triglyceride-glucose(TyG) index, recognized as a reliable marker for assessing insulin resistance, has received increasing attention in the field of cardiovascular diseases in recent years. Numerous studies have demonstrated a close association between the TyG index and the occurrence, progression, and prognosis of cardiovascular diseases. Moreover, body composition parameters, such as body mass index(BMI) and waist-to-height ratio(WHtR), have also been linked to the development and progression of heart failure. This article aims to explore the clinical implications of an elevated TyG index, particularly in combination with anthropometric indicators(BMI and WHtR), in the onset and adverse prognosis of heart failure, with the goal of providing a theoretical basis for clinical practice.

KeyWords： heart failure; triglyceride-glucose index; body mass index; waist-to-height ratio;

参考文献

[1] ZIAEIAN B, FONAROW G C. Epidemiology and aetiology of heart failure[J]. Nat Rev Cardiol, 2016,13(6):368-378.

[2] GUO W, ZHU W, WU J, et al. Triglyceride glucose index is associated with arterial stiffness and 10-year cardiovascular disease risk in a Chinese population[J]. Front Cardiovasc Med, 2021,8:585776.

[3] RAMíREZ-VéLEZ R, PéREZ-SOUSA Má，GONZáLEZ-RUíZ K, et al. Obesity-and lipid-related parameters in the identification of older adults with a high risk of prediabetes according to the American diabetes association:an analysis of the 2015 health,well-being, and aging study[J]. Nutrients, 2019,11(11):2654.

[4] SIMENTAL-MENDíA L E, RODRíGUEZ-MORáN M, GUERRERO-ROMERO F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects[J]. Metab Syndr Relat Disord, 2008,6(4):299-304.

[5] TAO L C, XU J N, WANG T T, et al. Triglyceride-glucose index as a marker in cardiovascular diseases:landscape and limitations[J]. Cardiovasc Diabetol, 2022,21(1):68.

[6] ZHOU Q, YANG J, TANG H, et al. High triglyceride-glucose(TyG)index is associated with poor prognosis of heart failure with preserved ejection fraction[J]. Cardiovasc Diabetol, 2023,22(1):263.

[7] CHEN J, WU K, LIN Y, et al. Association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population[J]. Cardiovasc Diabetol, 2023,22(1):320.

[8] ZHOU Y, WANG C, CHE H, et al. Association between the triglyceride-glucose index and the risk of mortality among patients with chronic heart failure:results from a retrospective cohort study in China[J]. Cardiovasc Diabetol, 2023,22(1):171.

[9] LI X, WANG J, NIU L, et al. Prevalence estimates of the insulin resistance and associated prevalence of heart failure among United Status adults[J]. BMC Cardiovasc Disord, 2023,23(1):294.

[10] SUN T, HUANG X, ZHANG B, et al. Prognostic significance of the triglyceride-glucose index for patients with ischemic heart failure after percutaneous coronary intervention[J]. Front Endocrinol(Lausanne), 2023,14:1100399.

[11] HUANG H, LI Q, LIU J, et al. Association between triglyceride glucose index and worsening heart failure in significant secondary mitral regurgitation following percutaneous coronary intervention[J]. Cardiovasc Diabetol, 2022,21(1):260.

[12] LI X, CHAN J S K, GUAN B, et al. Triglyceride-glucose index and the risk of heart failure:evidence from two large cohorts and a mendelian randomization analysis[J]. Cardiovasc Diabetol,2022,21(1):229.

[13] KENCHAIAH S, EVANS J C, LEVY D, et al. Obesity and the risk of heart failure[J]. N Engl J Med, 2002,347(5):305-313.

[14] YANG S, SHI X, LIU W, et al. Association between triglyceride glucose-body mass index and heart failure in subjects with diabetes mellitus or prediabetes mellitus:a cross-sectional study[J].Front Endocrinol(Lausanne), 2023,14:1294909.

[15] DANG K, WANG X, HU J, et al. The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease:NHANES 2003-2018[J]. Cardiovasc Diabetol, 2024,23(1):8.

[16] ZHENG D, CAI J, XU S, et al. The association of triglycerideglucose index and combined obesity indicators with chest pain and risk of cardiovascular disease in American population with pre-diabetes or diabetes[J]. Front Endocrinol(Lausanne),2024,15:1471535.

[17] NI W, JIANG R, XU D, et al. Association between insulin resistance indices and outcomes in patients with heart failure with preserved ejection fraction[J]. Cardiovasc Diabetol, 2025,24(1):32.

[18] DOU J, GUO C, WANG Y, et al. Association between triglyceride glucose-body mass and one-year all-cause mortality of patients with heart failure:a retrospective study utilizing the MIMIC-IV database[J]. Cardiovasc Diabetol, 2023,22(1):309.

[19] LYU L, WANG X, XU J, et al. Association between triglyceride glucose-body mass index and long-term adverse outcomes of heart failure patients with coronary heart disease[J]. Cardiovasc Diabetol, 2024,23(1):162.

[20] CUI C, QI Y, SONG J, et al. Comparison of triglyceride glucose index and modified triglyceride glucose indices in prediction of cardiovascular diseases in middle aged and older Chinese adults[J]. Cardiovasc Diabetol, 2024,23(1):185.

[21] VARDENY O, GUPTA D K, CLAGGETT B, et al. Insulin resistance and incident heart failure the ARIC study(atherosclerosis risk in communities)[J]. JACC Heart Fail, 2013,1(6):531-536.

[22] JAVEIDI A, SOLTANI S, ZARGAR M S, et al. Central fatness and risk of all cause mortality:systematic review and dose-response meta-analysis of 72 prospective cohort studies[J]. BMJ,2020,370:3324.

[23] SHENG G, LU S, XIE Q, et al. The usefulness of obesity and lipid-related indices to predict the presence of Non-alcoholic fatty liver disease[J]. Lipids Health Dis, 2021,20(1):134.

[24] MALEK M, KHAMSEH M E, CHEHREHREHGOSHA H, et al. Triglyceride glucose-waist to height ratio:a novel and effective marker for identifying hepatic steatosis in individuals with type 2 diabetes mellitus[J]. Endocrine, 2021,74(3):538-545.

[25] HUANG H, XIONG Y, ZHOU J, et al. The predictive value of estimated glucose disposal rate and its association with myocardial infarction, heart failure, atrial fibrillation and ischemic stroke[J]. Diabetes Obes Metab, 2025,27(3):1359-1368.

[26] ZHANG Y, WANG F, TANG J, et al. Association of triglyceride glucose-related parameters with all-cause mortality and cardiovascular disease in NAFLD patients:NHANES 1999-2018[J]. Cardiovasc Diabetol, 2024,23(1):262.

基本信息:

DOI：

中图分类号:R541.6

引用信息:

[1]任爱华,兰洪涛,任莉霞.三酰甘油—葡萄糖指数在心力衰竭中的应用进展[J].老年医学研究,2025,6(01):77-80.

基金信息:

请选择需要下载的pdf数据

老年医学研究

Summary